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Alpha fetoprotein (AFP): serial measurements to diagnose germ cell tumors in members with adenocarcinoma, or carcinoma not otherwise specified, involving mediastinal nodes or the diagnosis and monitoring of hepatocellular carcinoma (e.g., before considering liver transplantation).Alfa fetoprotein (AFP) for testing for hepatocellular carcinoma in hepatitis B carriers, or for persons with cirrhosis and one or more of the following risk factors: alcohol use alpha-1 antitrypsin deficiency Asian female at least 50 years of age Asian male at least 40 years of age family history of HCC genetic hemochromatosis hepatitis C nonalcoholic steatohepatitis and stage 4 primary biliary cirrhosis.Alpha fetoprotein (AFP) for the following indications: hepatocellular carcinoma mediastinal mass ovarian cancer pelvic mass testicular cancer testicular mass thymic carcinoma and thymoma.Repeat testing is considered experimental and investigational Afirma Thyroid FNA analysis for assessing fine needle aspiration samples from thyroid nodules that are indeterminate experimental for other indications.APC for familial adenomatous polyposis when criteria are met in CPB 0140 - Genetic Testing and for desmoid fibromatosis experimental for other indications.
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1p19q codeletion molecular cytogenetic analysis for astrocytomas and gliomas.For evaluation of jaundice, abnormal liver function tests (LFTs) or for obstruction/abnormality of the bile duct on liver imaging.For cholangiocarcinoma, gallbladder cancer, lung cancer, medullary thyroid cancer, metastatic breast cancer, mucinous ovarian cancer, and occult primary or.To monitor response to treatment for metastatic colorectal cancer or.To detect asymptomatic recurrence of colorectal cancer after surgical and/or medical treatment for the diagnosis of colorectal cancer (not as a screening test for colorectal cancer) or.Pancreatic cyst fluid CEA for distinguishing mucinous from non-mucinous malignant pancreatic cysts or.As a preoperative prognostic indicator in members with known colorectal carcinoma or mucinous appendiceal carcinoma when it will assist in staging and surgical treatment planning or.Carcinoembryonic antigen (CEA) for any of the following:.Prostate-specific antigen (PSA) for prostate cancer screening (see CPB 0521 - Prostate Cancer Screening), staging, monitoring response to therapy, and detecting disease recurrence.Aetna considers any of the following serum tumor markers for the stated indication medically necessary: